C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction.

Arampatzis, Spyridon; Chalikias, Georgios; Devetzis, Vasilios; Konstantinides, Stavros; Huynh-Do, Uyen; Tziakas, Dimitrios (2017). C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction. BMC nephrology, 18(1), p. 202. BioMed Central 10.1186/s12882-017-0611-9

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BACKGROUND Patients with acute myocardial infarction are at high risk for acute kidney injury. Novel biomarkers that can predict acute kidney injury in AMI may allow timely interventions. C-terminal fragment of agrin (CAF), a proteoglycan of the glomerular and tubular basement membrane, have been recently associated with rapid renal function deterioration and proximal tubular dysfunction. It is unknown whether elevated CAF levels may serve as a novel AKI biomarker in patients presenting with AMI. METHODS In 436 persons enrolled in a multicenter prospective observational cohort study of patients with acute myocardial infarction, we measured plasma and urine levels of several kidney injury biomarkers including CAF, neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18) and cystatin-C.The relationship between biomarker levels at baseline and the development of AKI and long-term mortality were analyzed after adjustment for demographic and clinical variables. RESULTS AKI incidence was up to 15% during hospitalization. The predictive accuracy for AKI of urinary CAF was similar to NGAL and superior to other tested kidney injury biomarkers. In a multivariate model that included all possible confounding variables only urinary CAF continued to be an independent marker for AKI (OR 1.35 95%CI 1.05 -1.74). During the 2 years follow-up, only plasma CAF levels remained a significant independent predictor of mortality (OR 2.5 95%CI 1.02-6.2; P = 0.04). CONCLUSIONS Elevated CAF levels are associated with AKI in patients with acute myocardial infarction. Our study provides preliminary evidence that CAF levels may predict AKI and mortality after AMI in low risk patients with relative preserved kidney function at baseline.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Arampatzis, Spyridon and Huynh-Do, Uyen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-2369

Publisher:

BioMed Central

Language:

English

Submitter:

Uyen Huynh-Do

Date Deposited:

01 Oct 2019 12:50

Last Modified:

27 Oct 2019 00:30

Publisher DOI:

10.1186/s12882-017-0611-9

PubMed ID:

28646861

Uncontrolled Keywords:

Acute kidney injury Acute myocardial infarction Biomarkers C-terminal agrin fragment

BORIS DOI:

10.7892/boris.131764

URI:

https://boris.unibe.ch/id/eprint/131764

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