Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies-meta-analysis of prospective studies.

Cammaroto, Giovanni; Costa, Francesco; Ruiz, Maria Victoria Garcia; Andò, Giuseppe; Vicini, Claudio; Montevecchi, Filippo; Galletti, Claudio; Galletti, Francesco; Valgimigli, Marco (2019). Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies-meta-analysis of prospective studies. European archives of oto-rhino-laryngology, 276(8), pp. 2331-2338. Springer 10.1007/s00405-019-05486-6

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PURPOSE Previous studies have shown an association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular events. Whether this association is mediated by an impairment of endothelial function, which is itself a driver of elevated cardiovascular risk, has yet to be clarified, as it is the eventual protective role of several OSAS treatments. The aim of our meta-analysis is to evaluate the effect of various OSAS treatments on endothelial function calculated by means of flow-mediated dilatation (FMD). METHODS We conducted a meta-analysis of prospective studies including patients affected by mild to severe OSAS treated with continuous positive airway pressure (CPAP), surgery, oral appliance and medical treatments. FMD was measured before and after treatment RESULTS: After pooling results from different treatment strategies, OSAS treatment showed a positive impact on endothelial function (Mean Difference [MD] = 2.58; 95% CI 1.95-3.20; p < 0.00001). CONCLUSIONS Our study supports the hypothesis that several modalities of treatment for OSAS positively impact endothelial function. Whether this effect also associates with an improvement of clinical outcomes remains to be ascertained.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0937-4477

Publisher:

Springer

Language:

English

Submitter:

Amanda Valle

Date Deposited:

12 Aug 2019 14:32

Last Modified:

12 Aug 2019 14:32

Publisher DOI:

10.1007/s00405-019-05486-6

PubMed ID:

31197532

Uncontrolled Keywords:

CPAP Endothelial function Meta-analysis OSAS Oral appliance Surgery

BORIS DOI:

10.7892/boris.131791

URI:

https://boris.unibe.ch/id/eprint/131791

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