Transcriptomic analyses of murine ventricular cardiomyocytes

Chevalier, Morgan; Vermij, Sarah H.; Wyler, Kurt; Gillet, Ludovic; Keller, Irene; Abriel, Hugues (2018). Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific data, 5(180170), p. 180170. Nature Publishing Group 10.1038/sdata.2018.170

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Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue have been available, but not yet for isolated ventricular cardiomyocytes. Our lab therefore collected comprehensive RNA-seq data from wildtype murine ventricular cardiomyocytes as well as from knockout models of the ion channel regulators CASK, dystrophin, and SAP97. We also elucidate ion channel expression from wild-type cells to help forward the debate about which ion channels are expressed in cardiomyocytes. Researchers studying the heart, and especially cardiac arrhythmias, may benefit from these cardiomyocyte-specific transcriptomic data to assess expression of genes of interest.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Chevalier, Morgan Yoann Edwin; Vermij, Sarah Helena; Wyler, Kurt and Abriel, Hugues

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2052-4463

Publisher:

Nature Publishing Group

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Sarah Helena Vermij

Date Deposited:

17 Sep 2019 14:16

Last Modified:

28 Oct 2019 18:05

Publisher DOI:

10.1038/sdata.2018.170

Related URLs:

PubMed ID:

30129933

BORIS DOI:

10.7892/boris.131819

URI:

https://boris.unibe.ch/id/eprint/131819

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