A closer look at the spectrum of drug-induced liver injury in sub-Saharan Africa.

Riebensahm, Carlotta; Ka, Daye; Sow, Abdoul; Semmo, Nasser; Wandeler, Gilles (2019). A closer look at the spectrum of drug-induced liver injury in sub-Saharan Africa. Expert review of clinical pharmacology, 12(9), pp. 875-883. Taylor & Francis 10.1080/17512433.2019.1638251

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Drug-induced liver injury (DILI) has become the most frequent cause of acute liver failure in high-income countries. However, little is known about the determinants of DILI in sub-Saharan Africa (SSA), where the prescription of antimicrobials as well as the use of potentially hepatotoxic traditional medicine are common. : Based on an extensive literature search, we summarize current data available on the epidemiology and risk factors of DILI in SSA. We discuss the most likely causes of DILI in the region, including antimicrobial therapies and traditional medicine. We also highlight research gaps as well as barriers to diagnosis and management of the condition, and explore ways to address these important challenges. : DILI is underestimated in SSA and several factors challenge its early diagnosis, including lack of information on the causes of DILI in the region, sub-optimal knowledge about the condition among clinicians, and structural difficulties faced by health care systems. In order to better prevent the occurrence of DILI and its complications, it is crucial to enhance awareness among health care providers and patients, adapt drug prescription habits and regulations, and improve current knowledge on the main risk factors for DILI, including host genetic and environmental determinants.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Semmo, Nasser and Wandeler, Gilles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1751-2433

Publisher:

Taylor & Francis

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

18 Sep 2019 15:58

Last Modified:

18 Sep 2019 16:00

Publisher DOI:

10.1080/17512433.2019.1638251

PubMed ID:

31269818

Uncontrolled Keywords:

acute liver failure adverse drug reaction drug-induced liver injury hepatotoxicity sub-Saharan Africa

BORIS DOI:

10.7892/boris.132003

URI:

https://boris.unibe.ch/id/eprint/132003

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