Impact of alcohol consumption on the risk of developing bladder cancer: a systematic review and meta-analysis.

Vartolomei, Mihai Dorin; Iwata, Takehiro; Roth, Beat; Kimura, Shoji; Mathieu, Romain; Ferro, Matteo; Shariat, Shahrokh F; Seitz, Christian (2019). Impact of alcohol consumption on the risk of developing bladder cancer: a systematic review and meta-analysis. World journal of urology, 37(11), pp. 2313-2324. Springer-Verlag 10.1007/s00345-019-02825-4

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BACKGROUND Epidemiologic studies that investigated alcohol consumption in relation to the risk of bladder cancer (BCa) have demonstrated inconsistent results. We conducted a systematic review and meta-analysis of the literature to investigate the association of alcohol including different types of alcoholic beverages consumption with the risk of BCa. MATERIALS AND METHODS A systematic search of Web of Science, Medline/PubMed and Cochrane library was performed in May 2018. Studies were considered eligible if they assessed the risk of BCa due to alcohol consumption (moderate or heavy dose) and different types of alcoholic beverages (moderate or heavy dose) in multivariable analysis in the general population (all genders, males or females) or compared with a control group of individuals without BCa. STUDY DESIGN observational cohorts or case-control. RESULTS Sixteen studies were included in this meta-analysis. Moderate and heavy alcohol consumption did not increase the risk of BCa in the entire population. Sub-group and sensitivity analyses revealed that heavy alcohol consumption increased significantly the risk of BCa in the Japanese population, RR 1.31 (95% CI 1.08-1.58, P < 0.01) in the multivariable analysis, and in males RR of 1.50 (95% CI 1.18-1.92, P < 0.01), with no significant statistical heterogeneity. Moreover, heavy consumption of spirits drinks increased the risk of BCa in males, RR 1.42 (95% CI 1.15-1.75, P < 0.01). CONCLUSION In this meta-analysis, moderate and heavy alcohol consumption did not increase the risk of bladder cancer significantly. However, heavy consumption of alcohol might increase the risk of BCa in males and in some specific populations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Roth, Beat

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0724-4983

Publisher:

Springer-Verlag

Language:

English

Submitter:

Jeannine Wiemann

Date Deposited:

19 Aug 2019 12:15

Last Modified:

05 Nov 2019 01:31

Publisher DOI:

10.1007/s00345-019-02825-4

PubMed ID:

31172281

Uncontrolled Keywords:

Alcohol consumption Bladder cancer Cancer risk

BORIS DOI:

10.7892/boris.132021

URI:

https://boris.unibe.ch/id/eprint/132021

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