Effects of local application of alendronate on early healing of extraction socket in dogs.

Saulacic, Nikola; Muñoz, Fernando; Kobayashi, Eizaburo; Chappuis, Vivianne; Gonzáles-Cantalapiedra, Antonio; Hofstetter, Wilhelm (2020). Effects of local application of alendronate on early healing of extraction socket in dogs. Clinical oral investigations, 24(4), pp. 1579-1589. Springer-Verlag 10.1007/s00784-019-03031-7

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OBJECTIVE

The aim of the present study was to assess the effects of alendronate (ALN) on bone remodeling following tooth extraction in a dog model.

MATERIAL AND METHODS

For the study, fifteen male Beagles dogs of approximately 12 months of age were used. Mesial roots of four mandibular premolars were endodontically treated, and the distal roots were removed. ALN concentrations of 0.5, 1, and 2 mg/mL were topically applied for 15 min, while a sterile saline was used as a negative control. After the healing period of 1, 2, and 8 weeks, the samples were analyzed by micro-CT and histology.

RESULTS

Treatment with ALN increased vertical distance between the lingual and the buccal crestal bones. While the ALN-treated sockets had preserved more lingual bone areas, control sockets showed better preservation of the buccal bone areas. ALN treatment resulted in more osteoid formation within the extraction sockets compared with the control. Higher bone volume was found in ALN groups than in the control at 2-week and 8-week healing periods, reaching the significant difference only for the extraction sockets pooled for the ALN treatment.

CONCLUSIONS

Although ALN treatment could not prevent buccal bone resorption following tooth extraction in dogs, it proved beneficial for the preservation of the lingual bone and formation of new bone within the socket. There was no clear relation between the ALN dosages and the alterations within the extraction sockets.

CLINICAL RELEVANCE

ALN affects bone remodeling of the extraction socket. The optimal concentration remains to be determined in future studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Knochenbiologie & Orthopädische Forschung

04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology

UniBE Contributor:

Saulacic, Nikola; Kobayashi, Eizaburo; Chappuis, Vivianne and Hofstetter, Wilhelm

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-6981

Publisher:

Springer-Verlag

Language:

English

Submitter:

Caroline Balz

Date Deposited:

30 Jul 2019 14:28

Last Modified:

03 Apr 2020 01:30

Publisher DOI:

10.1007/s00784-019-03031-7

PubMed ID:

31346723

Uncontrolled Keywords:

Alendronate Bone remodeling Dog model Extraction socket

BORIS DOI:

10.7892/boris.132207

URI:

https://boris.unibe.ch/id/eprint/132207

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