Otitis in a cat associated with Corynebacterium provencense.

Kittl, Sonja; Brodard, Isabelle; Rychener, Lorenz; Jores, Jörg; Roosje, Petra; Gobeli Brawand, Stefanie (2018). Otitis in a cat associated with Corynebacterium provencense. BMC veterinary research, 14(1), p. 200. BioMed Central 10.1186/s12917-018-1526-9

[img]
Preview
Text
kittl_et_al_otitis.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

BACKGROUND The role of corynebacteria in canine and feline otitis has not been investigated in detail; however, members of this genus are increasingly recognized as pathogens of otitis in both human and veterinary medicine. CASE PRESENTATION Here we report the first case of feline otitis associated with the recently described species Corynebacterium provencense. A seven-month old cat presented with a head tilt and ataxia was diagnosed with peripheral vestibular syndrome associated with an otitis media/interna. This took place 6 weeks after resection of a polyp, having initially shown a full recovery with topical ofloxacin and glucocorticoid treatment. Bacteriology of an ear swab yielded a pure culture of corynebacteria, which could not be identified at the species level using routine methods. However, the 16S rRNA gene sequence was 100% identical to the recently published novel corynebacterium species, Corynebacterium provencense. Whole genome sequencing of the cat isolate and calculation of average nucleotide identity (99.1%) confirmed this finding. The cat isolate was found to contain additional presumptive iron acquisition genes that are likely to encode virulence factors. Furthermore, the strain tested resistant to clindamycin, penicillin and ciprofloxacin. The cat was subsequently treated with chloramphenicol, which lead to clinical improvement. CONCLUSION Corynebacteria from otitis cases are not routinely identified at the species level and not tested for antimicrobial susceptibility in veterinary laboratories, as they are not considered major pathogens. This may lead to underreporting of this genus or animals being treated with inappropriate antimicrobials since corynebacteria are often resistant to multiple drugs.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Kittl, Sonja; Brodard, Isabelle; Rychener, Lorenz; Jores, Jörg; Roosje, Petra and Gobeli, Stefanie

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Sonja Kittl

Date Deposited:

20 Sep 2019 14:42

Last Modified:

04 Nov 2019 10:37

Publisher DOI:

10.1186/s12917-018-1526-9

PubMed ID:

29940943

Uncontrolled Keywords:

Corynebacterium Feline otitis Neglected pathogen

BORIS DOI:

10.7892/boris.132383

URI:

https://boris.unibe.ch/id/eprint/132383

Actions (login required)

Edit item Edit item
Provide Feedback