Mood Effects After Deep Brain Stimulation for Parkinson's Disease: An Update.

Accolla, Ettore A; Pollo, Claudio (2019). Mood Effects After Deep Brain Stimulation for Parkinson's Disease: An Update. Frontiers in neurology, 10(617), p. 617. Frontiers Media S.A. 10.3389/fneur.2019.00617

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Depression in Parkinson's Disease (PD) is a prevalent and invalidating symptom. Deep brain stimulation (DBS) allows for an improvement of PD motor features, but its effects on mood are difficult to predict. Here, we review the evidence regarding mood effects after DBS of either subthalamic nucleus (STN) or globus pallidus pars interna (GPi). Different influences of multiple factors contribute to impact the neuropsychiatric outcome after surgery. Psychosocial presurgical situation, postsurgical coping mechanisms, dopaminergic treatment modifications, and direct effects of the stimulation of either target are all playing a distinct role on the psychological well-being of patients undergoing DBS. No clear advantage of either target (STN vs. GPi) has been consistently found, both being effective and with a favorable profile on depression symptoms. However, specific patients' characteristics or anatomical considerations can guide the neurosurgeon in the target choice. Further research together with technological advances are expected to confine the stimulation area within dysfunctional circuits causing motor symptoms of PD.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-2295

Publisher:

Frontiers Media S.A.

Language:

English

Submitter:

Nicole Söll

Date Deposited:

27 Aug 2019 09:29

Last Modified:

23 Oct 2019 10:27

Publisher DOI:

10.3389/fneur.2019.00617

PubMed ID:

31258509

Uncontrolled Keywords:

DBS GPi STN basal ganglia depression hypomania

BORIS DOI:

10.7892/boris.132396

URI:

https://boris.unibe.ch/id/eprint/132396

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