Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System

van Eimeren, Thilo; Antonini, Angelo; Berg, Daniela; Bohnen, Nico; Ceravolo, Roberto; Drzezga, Alexander; Höglinger, Günter U.; Higuchi, Makoto; Lehericy, Stephane; Lewis, Simon; Monchi, Oury; Nestor, Peter; Ondrus, Matej; Pavese, Nicola; Peralta, María Cecilia; Piccini, Paola; Pineda-Pardo, José Ángel; Rektorová, Irena; Rodríguez-Oroz, María; Rominger, Axel; ... (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimer's & dementia: Diagnosis, Assessment & Disease Monitorin, 11, pp. 301-309. Elsevier 10.1016/j.dadm.2019.01.011

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Introduction: Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials in atypical parkinsonian disorders. Methods: To promote standardized use of neuroimaging biomarkers for clinical trials, we aimed to develop a conceptual framework to characterize in more detail the kind of neuroimaging biomarkers needed in atypical parkinsonian disorders, identify the current challenges in ascribing utility of these biomarkers, and propose criteria for a system that may guide future studies. Results: As a consensus outcome, we describe the main challenges in ascribing utility of neuroimaging biomarkers in atypical parkinsonian disorders, and we propose a conceptual framework that includes a graded system for the description of utility of a specific neuroimaging measure. We included separate categories for the ability to accurately identify an intention-to-treat patient population early in the disease (Early), to accurately detect a specific underlying pathology (Specific), and the ability to monitor disease progression (Progression). Discussion: We suggest that the advancement of standardized neuroimaging in the field of atypical parkinsonian disorders will be furthered by a well-defined reference frame for the utility of biomarkers. The proposed utility system allows a detailed and graded description of the respective strengths of neuroimaging biomarkers in the currently most relevant areas of application in clinical trials.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2352-8729

Publisher:

Elsevier

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

12 Dec 2019 11:36

Last Modified:

12 May 2020 08:00

Publisher DOI:

10.1016/j.dadm.2019.01.011

PubMed ID:

30984816

Uncontrolled Keywords:

Biomarker; CBD; CBS; Harmonization; MRI; MSA; Multicentric; Multisite; Neurodegeneration; Neuroimaging; PET; PSP; Trials

BORIS DOI:

10.7892/boris.132423

URI:

https://boris.unibe.ch/id/eprint/132423

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