Dietary antioxidant capacity and risk of type 2 diabetes mellitus, prediabetes and insulin resistance: the Rotterdam Study.

van der Schaft, Niels; Schoufour, Josje D; Nano, Jana; Kiefte-de Jong, Jessica C; Muka, Taulant; Sijbrands, Eric J G; Ikram, M Arfan; Franco, Oscar H.; Voortman, Trudy (2019). Dietary antioxidant capacity and risk of type 2 diabetes mellitus, prediabetes and insulin resistance: the Rotterdam Study. European journal of epidemiology, 34(9), pp. 853-861. Springer 10.1007/s10654-019-00548-9

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Intake of individual antioxidants has been related to a lower risk of type 2 diabetes. However, the overall diet may contain many antioxidants with additive or synergistic effects. Therefore, we aimed to determine associations between total dietary antioxidant capacity and risk of type 2 diabetes, prediabetes and insulin resistance. We estimated the dietary antioxidant capacity for 5796 participants of the Rotterdam Study using a ferric reducing ability of plasma (FRAP) score. Of these participants, 4957 had normoglycaemia and 839 had prediabetes at baseline. We used covariate-adjusted proportional hazards models to estimate associations between FRAP and risk of type 2 diabetes, risk of type 2 diabetes among participants with prediabetes, and risk of prediabetes. We used linear regression models to determine the association between FRAP score and insulin resistance (HOMA-IR). We observed 532 cases of incident type 2 diabetes, of which 259 among participants with prediabetes, and 794 cases of incident prediabetes during up to 15 years of follow-up. A higher FRAP score was associated with a lower risk of type 2 diabetes among the total population (HR per SD FRAP 0.84, 95% CI 0.75; 0.95) and among participants with prediabetes (HR 0.85, 95% CI 0.73; 0.99), but was not associated with risk of prediabetes. Dietary FRAP was also inversely associated with HOMA-IR (β - 0.04, 95% CI - 0.06; - 0.03). Effect estimates were generally similar between sexes. The findings of this population-based study emphasize the putative beneficial effects of a diet rich in antioxidants on insulin resistance and risk of type 2 diabetes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Muka, Taulant and Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0393-2990

Publisher:

Springer

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

12 Aug 2019 16:32

Last Modified:

23 Oct 2019 03:32

Publisher DOI:

10.1007/s10654-019-00548-9

PubMed ID:

31399939

Uncontrolled Keywords:

Diet Dietary antioxidant capacity Insulin resistance Prediabetes Type 2 diabetes

BORIS DOI:

10.7892/boris.132555

URI:

https://boris.unibe.ch/id/eprint/132555

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