Response of the rat spinal cord to X-ray microbeams

Laissue, Jean A; Bartzsch, Stefan; Blattmann, Hans; Bräuer-Krisch, Elke; Bravin, Alberto; Dalléry, Dominique; Djonov, Valentin; Hanson, Albert L; Hopewell, John W; Kaser-Hotz, Barbara; Keyriläinen, Jani; Laissue, Pierre Philippe; Miura, Michiko; Serduc, Raphaël; Siegbahn, Albert E; Slatkin, Daniel N (2013). Response of the rat spinal cord to X-ray microbeams. Radiotherapy and oncology, 106(1), pp. 106-111. Amsterdam: Elsevier 10.1016/j.radonc.2012.12.007

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BACKGROUND AND PURPOSE: To quantify the late dose-related responses of the rat cervical spinal cord to X-ray irradiations by an array of microbeams or by a single millimeter beam. MATERIALS AND METHODS: Necks of anesthetized rats were irradiated transversely by an 11mm wide array of 52 parallel, 35μm wide, vertical X-ray microbeams, separated by 210μm intervals between centers. Comparison was made with rats irradiated with a 1.35mm wide single beam of similar X-rays. Rats were killed when paresis developed, or up to 383days post irradiation (dpi). RESULTS: Microbeam peak/valley doses of ≈357/12.7Gy to 715/25.4Gy to an 11mm long segment of the spinal cord, or single beam doses of ≈146-454Gy to a 1.35mm long segment caused foreleg paresis and histopathologically verified spinal cord damage; rats exposed to peak/valley doses up to 253/9Gy were paresis-free at 383dpi. CONCLUSIONS: Whereas microbeam radiation therapy [MRT] for malignant gliomas implanted in rat brains can be safe, palliative or curative, the high tolerance of normal rat spinal cords to similar microbeam exposures justifies testing MRT for autochthonous malignancies in the central nervous system of larger animals with a view to subsequent clinical applications.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Laissue, Jean

ISSN:

0167-8140

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

08 Jun 2016 10:30

Publisher DOI:

10.1016/j.radonc.2012.12.007

PubMed ID:

23321495

Web of Science ID:

000316303800018

URI:

https://boris.unibe.ch/id/eprint/13256 (FactScience: 219771)

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