Martinez, Evelyn Pamela; Cepeda, Magda; Jovanoska, Marija; Bramer, Wichor M; Schoufour, Josje; Glisic, Marija; Verbon, Annelies; Franco, Oscar H (2019). Seasonality of antimicrobial resistance rates in respiratory bacteria: A systematic review and meta-analysis. PLoS ONE, 14(8), e0221133. Public Library of Science 10.1371/journal.pone.0221133
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BACKGROUND
Antimicrobial resistance (AMR) rates may display seasonal variation. However, it is not clear whether this seasonality is influenced by the seasonal variation of infectious diseases, geographical region or differences in antibiotic prescription patterns. Therefore, we assessed the seasonality of AMR rates in respiratory bacteria.
METHODS
Seven electronic databases (Embase.com, Medline Ovid, Cochrane CENTRAL, Web of Science, Core Collection, Biosis Ovid, and Google Scholar), were searched for relevant studies from inception to Jun 25th, 2019. Studies describing resistance rates of Streptococcus pneumoniae and Haemophilus influenzae were included in this review. By using random-effects meta-analysis, pooled odd ratios of seasonal AMR rates were calculated using winter as the reference group. Pooled odd ratios were obtained by antibiotic class and geographical region.
RESULTS
We included 13 studies, of which 7 were meta-analyzed. Few studies were done in H. influenzae, thus this was not quantitively analyzed. AMR rates of S. pneumoniae to penicillins were lower in other seasons than in winter with pooled OR = 0.71; 95% CI = 0.65-0.77; I2 = 0.0%, and to all antibiotics with pooled OR = 0.68; 95% CI = 0.60-0.76; I2 = 14.4%. Irrespective of geographical region, the seasonality of AMR rates in S. pneumoniae remained the same.
CONCLUSION
The seasonality of AMR rates could result from the seasonality of infectious diseases and its accompanied antibiotic use.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Franco Duran, Oscar Horacio |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
27 Aug 2019 12:09 |
Last Modified: |
10 May 2023 05:49 |
Publisher DOI: |
10.1371/journal.pone.0221133 |
PubMed ID: |
31415656 |
BORIS DOI: |
10.7892/boris.132704 |
URI: |
https://boris.unibe.ch/id/eprint/132704 |
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