In situ Reconstruction of Infected Groin Pseudoaneurysms in Drug Abusers With Biological Grafts.

Becker, Daniel; Béguin, Mathieu; Weiss, Salome; Wyss, Thomas R.; Schmidli, Jürg; Makaloski, Vladimir (2019). In situ Reconstruction of Infected Groin Pseudoaneurysms in Drug Abusers With Biological Grafts. European journal of vascular and endovascular surgery EJVES, 58(4), pp. 592-598. Elsevier 10.1016/j.ejvs.2019.04.034

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OBJECTIVES The aim of this study was to evaluate outcomes after in situ reconstruction using biological grafts in infected groin pseudoaneurysms in drug abusers. METHODS This was a single centre retrospective analysis of all patients undergoing in situ reconstruction with biological vascular grafts for infected groin pseudoaneurysms in drug abusers from 2000 to 2017. Outcome measures included wound healing problems, re-infection, graft patency, lower limb amputation, and mortality. RESULTS Twenty-two patients (14 male) with a median age of 39 years (range 27-49) were identified. Fifteen patients (68%) underwent urgent in situ reconstruction with a xenograft, five patients (23%) with a homograft, and two patients (9%) with an autologous vein. There were no in hospital deaths, in hospital re-infections, or early major limb amputations. Four (18%) patients developed wound healing complications requiring re-operation. During a median follow up of 56 months (range 13-180 months), six patients (27%) developed re-infection requiring complete graft replacement with a new biological graft. Thereafter, three (14%) had re-re-infection. Seven patients (32%) had graft occlusions: two were treated endovascularly, two underwent re-operation, and three were treated conservatively. Two patients (9%) had patent grafts but significant stenosis: one had successful angioplasty and another one was left untreated. One patient required above knee amputation, resulting in an overall major amputation rate of 4%. Estimated primary patency was 87% after one year and 40% after five years. Six patients (27%) died during follow up from non-vascular causes. CONCLUSIONS In situ reconstruction using biological grafts of infected groin pseudoaneurysms in drug abusers can be achieved with no peri-operative graft related complications, although rates of wound complications may be high. In the longer term, a significant number of patients develop re-infection, graft occlusion, or stenosis, although the amputation rate remains low. The management of this demanding group of patients remains a major challenge.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Becker, Daniel; Weiss, Salome; Wyss, Thomas; Schmidli, Jürg and Makaloski, Vladimir

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1078-5884

Publisher:

Elsevier

Language:

English

Submitter:

Claudia Stalder

Date Deposited:

27 Aug 2019 13:08

Last Modified:

24 Oct 2019 02:24

Publisher DOI:

10.1016/j.ejvs.2019.04.034

PubMed ID:

31422048

Uncontrolled Keywords:

Biological grafts Drug abusers In situ revascularisation Mycotic pseudo-aneurysm

BORIS DOI:

10.7892/boris.132805

URI:

https://boris.unibe.ch/id/eprint/132805

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