Short-term fully closed-loop insulin delivery using faster insulin aspart compared to standard insulin aspart in type 2 diabetes.

Bally, Lia; Herzig, David; Ruan, Yue; Wilinska, Malgorzata E; Semmo, Mariam; Vogt, Andreas; Wertli, Maria M.; Vogt, Bruno; Stettler, Christoph; Hovorka, Roman (2019). Short-term fully closed-loop insulin delivery using faster insulin aspart compared to standard insulin aspart in type 2 diabetes. (In Press). Diabetes, obesity & metabolism Wiley 10.1111/dom.13861

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We evaluated the efficacy and safety of short-term fully closed-loop insulin delivery using faster versus standard insulin aspart in type 2 diabetes. Fifteen adults with insulin-treated type 2 diabetes underwent 22 hours of closed-loop insulin delivery with either faster or standard insulin aspart in a double-blind randomised crossover design. Basal-bolus regimen was replaced by model predictive control algorithm-directed insulin delivery based on sensor glucose levels. The primary outcome was time with plasma glucose in target range (5.6-10.0mmol/l) and did not differ between treatments (mean difference [95%CI] -3.3% [8.2;1.7], p=0.17). Mean glucose and glucose variability were comparable, as was time spent below and above target range. Hypoglycaemia (<3.5mmol/l) occurred once with faster insulin aspart and twice with standard insulin aspart. Mean total insulin dose was higher with faster insulin aspart (mean difference [95%CI] 3.7U [0.7;6.8], p=0.021). No episodes of severe hypoglycaemia or other serious adverse events occurred. In conclusion, short-term fully closed-loop in type 2 diabetes may require higher dose of faster insulin aspart compared to standard insulin aspart to achieve comparable glucose control. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Bally, Lia Claudia; Herzig, David; Semmo, Mariam; Vogt, Andreas; Wertli, Maria Monika; Vogt, Bruno and Stettler, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1463-1326

Publisher:

Wiley

Language:

English

Submitter:

Christine Baumgartner

Date Deposited:

04 Sep 2019 14:59

Last Modified:

04 Sep 2019 14:59

Publisher DOI:

10.1111/dom.13861

PubMed ID:

31464063

BORIS DOI:

10.7892/boris.132980

URI:

https://boris.unibe.ch/id/eprint/132980

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