Individualized prediction of leukemia-free survival after autologous stem cell transplantation in acute myeloid leukemia.

Shouval, Roni; Labopin, Myriam; Gorin, Norbert C; Bomze, David; Houhou, Mohamed; Blaise, Didier; Zuckerman, Tsila; Baerlocher, Gabriela M.; Capria, Saveria; Forcade, Edouard; Huynh, Anne; Saccardi, Riccardo; Martino, Massimo; Schaap, Michel; Wu, Depei; Mohty, Mohamad; Nagler, Arnon (2019). Individualized prediction of leukemia-free survival after autologous stem cell transplantation in acute myeloid leukemia. Cancer, 125(20), pp. 3566-3573. John Wiley & Sons 10.1002/cncr.32344

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BACKGROUND Autologous stem cell transplantation (ASCT) is a potential consolidation therapy for acute myeloid leukemia (AML). This study was designed to develop a prediction model for leukemia-free survival (LFS) in a cohort of patients with de novo AML treated with ASCT during their first complete remission. METHODS This was a registry study of 956 patients reported to the European Society for Blood and Marrow Transplantation. The primary outcome was LFS. Multivariate Cox regression modeling with backward selection was used to select variables for the construction of the nomogram. The nomogram's performance was evaluated with discrimination (the area under the receiver operating characteristic curve [AUC]) and calibration. RESULTS Age and cytogenetic risk (with or without FMS-like tyrosine kinase 3 internal tandem duplication) were predictive of LFS and were used for the construction of the nomogram. Each factor in the nomogram was ascribed points according to its predictive weight. Through the calculation of the total score, the probability of LFS at 1, 3, and 5 years for each patient could be estimated. The discrimination of the nomogram, measured as the AUC, was 0.632 (95% confidence interval [CI], 0.595-0.669), 0.670 (95% CI, 0.635-0.705), and 0.687 (95% CI, 0.650-0.724), respectively. Further validation with bootstrapping showed similar AUCs (0.629 [95% CI, 0.597-0.657], 0.667 [95% CI, 0.633-0.699], and 0.679 [95% CI, 0.647-0.712], respectively), and this suggested that the model was not overfitted. Calibration was excellent. Patients were stratified into 4 incremental 5-year prognostic groups, with the probabilities of LFS and overall survival ranging from 25% to 64% and from 33% to 79%, respectively. CONCLUSIONS The Auto-AML nomogram score is a tool integrating individual prognostic factors to provide a probabilistic estimation of LFS after ASCT for patients with AML.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Baerlocher, Gabriela M.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0008-543X

Publisher:

John Wiley & Sons

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

20 Sep 2019 12:28

Last Modified:

22 Oct 2019 17:05

Publisher DOI:

10.1002/cncr.32344

PubMed ID:

31225904

Uncontrolled Keywords:

acute myeloid leukemia autologous stem cell transplantation leukemia-free survival nomogram prediction

BORIS DOI:

10.7892/boris.133378

URI:

https://boris.unibe.ch/id/eprint/133378

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