The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.

Häfliger, Pascal; Charles, Roch-Philippe (2019). The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer. International journal of molecular sciences, 20(10) Molecular Diversity Preservation International MDPI 10.3390/ijms20102428

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Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Häfliger, Pascal and Charles, Roch-Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

26 Sep 2019 09:36

Last Modified:

23 Oct 2019 03:38

Publisher DOI:

10.3390/ijms20102428

PubMed ID:

31100853

Uncontrolled Keywords:

cancer inhibitor l-type amino acid transporter LAT1 preclinical studies targeted therapy

BORIS DOI:

10.7892/boris.133481

URI:

https://boris.unibe.ch/id/eprint/133481

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