Use of PRECISE-DAPT Score and Admission Platelet Count to Predict Mortality Risk in Patients With Acute Coronary Syndrome.

Morici, Nuccia; Tavecchia, Giovanni A; Antolini, Laura; Caporale, Maria R; Cantoni, Silvia; Bertuccio, Paola; Sacco, Alice; Meani, Paolo; Viola, Giovanna; Brunelli, Dario; Oliva, Fabrizio; Lombardi, Federico; Segreto, Antonio; Oreglia, Jacopo A; La Vecchia, Carlo; Cattaneo, Marco; Valgimigli, Marco; Savonitto, Stefano (2019). Use of PRECISE-DAPT Score and Admission Platelet Count to Predict Mortality Risk in Patients With Acute Coronary Syndrome. Angiology, 70(9), pp. 867-877. Sage 10.1177/0003319719848547

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The PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent Dual Antiplatelet Therapy (PRECISE-DAPT) score has been validated to predict bleeding complications in patients undergoing stent implantation and dual antiplatelet therapy. This score does not include the platelet count (PC), which has been shown to be an independent marker of mortality in patients with acute coronary syndrome (ACS). We assessed the role of the PRECISE-DAPT score calculated on admission for mortality risk prediction and evaluated whether the predictive accuracy of this score improved by adding the PC. In a retrospective cohort study of 1000 patients with ACS, after adjustment for relevant covariates, a PRECISE-DAPT score ≥25 was independently associated with mortality (hazard ratio [HR]: 7.91; 95% confidence interval [CI]: 4.37-14.30). When this score was combined with PC, compared to patients with PRECISE-DAPT <25 and PC ≥150 × 109/L, the adjusted HR was 7.2 (95% CI 2.4-21.6) for those with PRECISE-DAPT <25 and PC <150 × 109/L; 10.7 (95% CI: 5.2-21.9) for those with PRECISE-DAPT ≥25 and PC ≥150 × 109/L; and 17.9 (95% CI 7.0-45.4) for those with PRECISE-DAPT ≥25 and PC <150 × 109/L. Selecting thresholds for high-risk designation, the PRECISE-DAPT score integrated with PC had a higher prediction value, compared to the PRECISE-DAPT and Global Registry of Acute Coronary Events scores.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0003-3197

Publisher:

Sage

Language:

English

Submitter:

Amanda Valle

Date Deposited:

26 Sep 2019 14:01

Last Modified:

05 Dec 2022 15:30

Publisher DOI:

10.1177/0003319719848547

PubMed ID:

31088127

Uncontrolled Keywords:

acute coronary syndrome risk score thrombocytopenia

BORIS DOI:

10.7892/boris.133487

URI:

https://boris.unibe.ch/id/eprint/133487

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