Symptom-specific effectiveness of an internet-based intervention in the treatment of mild to moderate depressive symptomatology: The potential of network estimation techniques.

Boschloo, Lynn; Cuijpers, Pim; Karyotaki, Eirini; Berger, Thomas; Moritz, Steffen; Meyer, Björn; Klein, Jan Philipp (2019). Symptom-specific effectiveness of an internet-based intervention in the treatment of mild to moderate depressive symptomatology: The potential of network estimation techniques. Behaviour research and therapy, 122, p. 103440. Elsevier 10.1016/j.brat.2019.103440

[img] Text
1-s2.0-S0005796719301263-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (455kB) | Request a copy

The internet-based intervention Deprexis® has proven to be effective in improving overall depression severity. The current pragmatic randomized controlled trial included 1013 participants with mild to moderate symptomatology and aimed to identify the symptom-specific effects of the internet-based intervention Deprexis (intervention group) in comparison to care as usual (control group). All participants -in both conditions- were permitted to use any type of treatment. Of the nine considered symptoms (assessed with the Patient Health Questionnaire), seven showed larger improvements in the intervention condition relative to care as usual (effect sizes ranging from 0.15 to 0.31). No significant differences were found for the two other symptoms. In a next step, a network was estimated including treatment condition as well as changes in all nine symptoms. The resulting network suggests that four of the seven identified symptom-specific effects were direct, whereas the three other symptom-specific effects were indirect and could be explained by effects on other symptoms. Lastly, exploratory analyses showed that the intervention was more effective in improving overall depression severity for participants with higher scores on those four symptoms that were directly affected by the intervention; consequently, the network estimation techniques showed potential in precision psychiatry.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Berger, Thomas

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

0005-7967

Publisher:

Elsevier

Language:

English

Submitter:

Dania Gioia Spagnuolo

Date Deposited:

30 Sep 2019 14:20

Last Modified:

24 Oct 2019 05:49

Publisher DOI:

10.1016/j.brat.2019.103440

PubMed ID:

31542565

Uncontrolled Keywords:

CBT Depressive symptoms Internet-based intervention Network estimation techniques Precision psychiatry

BORIS DOI:

10.7892/boris.133532

URI:

https://boris.unibe.ch/id/eprint/133532

Actions (login required)

Edit item Edit item
Provide Feedback