Health economic evaluation of a web-based intervention for depression: the EVIDENT-trial, a randomized controlled study.

Gräfe, Viola; Berger, Thomas; Hautzinger, Martin; Hohagen, Fritz; Lutz, Wolfgang; Meyer, Björn; Moritz, Steffen; Rose, Matthias; Schröder, Johanna; Späth, Christina; Klein, Jan Philipp; Greiner, Wolfgang (2019). Health economic evaluation of a web-based intervention for depression: the EVIDENT-trial, a randomized controlled study. Health economics review, 9(1), p. 16. Springer 10.1186/s13561-019-0233-y

document.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

BACKGROUND Depression often remains undiagnosed or treated inadequately. Web-based interventions for depression may improve accessibility of treatment and reduce disease-related costs. This study aimed to examine the potential of the web-based cognitive behavioral intervention "deprexis" in reducing disease-related costs. METHODS Participants with mild to moderate depressive symptoms were recruited and randomized to either a 12-week web-based intervention (deprexis) in addition to care as usual (intervention group) or care as usual (control group). Outcome measures were health-related resource use, use of medication and incapacity to work as well as relating direct health care costs. Outcomes were assessed on patients' self-report at baseline, three months and six months. RESULTS A total of 1013 participants were randomized. In both groups total direct health care costs decreased during the study period, but changes from baseline did not significantly differ between study groups. Numeric differences between study groups existed in outpatient treatment costs. They could be attributed to differences in changes of costs for psychotherapeutic treatment from baseline. Whereas costs for psychotherapeutic treatment decreased in the intervention group, costs increased in the control group (- 16.8% (€80) vs. + 14.7% (€60)) (tdf = 685 = 2.57; p = 0.008). CONCLUSION The study indicates the health economic potential of innovative e-mental-health programs. There is evidence to suggest that the use of deprexis over a period of 12 weeks leads to a decrease in outpatient treatment cost, especially in those related to different types of psychotherapeutic treatment.

Item Type:

Journal Article (Original Article)


07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Berger, Thomas


100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health








Melanie Best

Date Deposited:

30 Sep 2019 14:43

Last Modified:

30 Mar 2020 14:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Depression Deprexis E-mental-health Economic issues Health economic evaluation Outcome studies Randomized controlled trial




Actions (login required)

Edit item Edit item
Provide Feedback