Associations of psychosis-risk symptoms with quality of life and self-rated health in the Community

Michel, Chantal; Schmidt, Stefanie J.; Schnyder, Nina; Flückiger, Rahel; Käufeler, Iljana; Schimmelmann, Benno G.; Schultze-Lutter, Frauke (2019). Associations of psychosis-risk symptoms with quality of life and self-rated health in the Community. European psychiatry, 62, pp. 116-123. Elsevier Masson SAS 10.1016/j.eurpsy.2019.08.008

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Background: Understanding factors related to poor quality of life (QoL) and self-rated health (SRH) in clinical high-risk (CHR) for psychosis is important for both research and clinical applications. We investigated the associations of both constructs with CHR symptoms, axis-I disorders, and sociodemographic variables in a community sample. Methods: In total, 2683 (baseline) and 829 (3-year follow-up) individuals of the Swiss Canton of Bern (age-at-baseline: 16–40 years) were interviewed by telephone regarding CHR symptoms, using the Schizophrenia Proneness Instrument for basic symptoms, the Structured Interview for Psychosis-Risk Syndromes for ultra-high risk (UHR) symptoms, the Mini-International Neuropsychiatric Interview for current axis-I disorders, the Brief Multidimensional Life Satisfaction Scale for QoL, and the 3-level EQ-5D for SRH. Results: In cross-sectional structural equation modelling, lower SRH was exclusively significantly associated with higher age, male gender, lower education, and somatoform disorders. Poor QoL was exclusively associated only with eating disorders. In addition, both strongly interrelated constructs were each associated with affective, and anxiety disorders, UHR and, more strongly, basic symptoms. Prospectively, lower SRH was predicted by lower education and anxiety disorders at baseline, while poorer QoL was predicted by affective disorders at baseline. Conclusions:When present, CHR, in particular basic symptoms are already distressful for individuals of the community and associated with poorer subjective QoL and health. Therefore, the symptoms are clinically relevant by themselves, even when criteria for a CHR state are not fulfilled. Yet, unlike affective and anxiety disorders, CHR symptoms seem to have no long-term influence on QoL and SRH.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Michel, Chantal; Schmidt, Stefanie Julia; Schnyder, Nina and Flückiger, Rahel


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology
100 Philosophy > 150 Psychology




Elsevier Masson SAS




Chantal Michel

Date Deposited:

04 Oct 2019 14:34

Last Modified:

23 Oct 2019 13:05

Publisher DOI:





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