Striatal responsiveness to reward under threat-of-shock and working memory load: A preliminary study.

Gaillard, Claudie; Guillod, Matthias; Ernst, Monique; Torrisi, Salvatore; Federspiel, Andrea; Schoebi, Dominik; Recabarren, Romina E; Ouyang, Xinyi; Mueller-Pfeiffer, Christoph; Horsch, Antje; Homan, Philipp; Wiest, Roland; Hasler, Gregor; Martin-Soelch, Chantal (2019). Striatal responsiveness to reward under threat-of-shock and working memory load: A preliminary study. Brain and Behavior, 9(10), e01397. Wiley 10.1002/brb3.1397

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INTRODUCTION Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational and hedonic processes in healthy adults. MATERIALS AND METHODS A reward task, involving stress with unpredictable mild electric shocks, was conducted in 23 healthy adults aged 20-37 (mean age: 24.7 ± 0.9; 14 females) during functional magnetic resonance imaging (fMRI). Manipulation included the use of (a) monetary reward for reinforcement, (b) threat-of-shock as the stressor, and (c) a spatial working memory task with two levels of difficulty (low and high load) for cognitive load. Reward-related activation was investigated in a priori three regions of interest, the nucleus accumbens (NAcc), caudate nucleus, and putamen. RESULTS During anticipation, threat-of-shock or cognitive load did not affect striatal responsiveness to reward. Anticipated reward increased activation in the ventral and dorsal striatum. During feedback delivery, both threat-of-shock and cognitive effort modulated striatal activation. Higher working memory load blunted NAcc responsiveness to reward delivery, while stress strengthened caudate nucleus reactivity regardless reinforcement or load. CONCLUSIONS These findings provide initial evidence that both stress and cognitive load modulate striatal responsiveness during feedback delivery but not during anticipation in healthy adults. Of clinical importance, sustained stress exposure might go along with dysregulated arousal, increasing therefore the risk for the development of maladaptive incentive-triggered motivation. This study brings new insight that might help to build a framework to understand common stress-related disorders, given that these psychiatric disorders involve disturbances of the reward system, cognitive deficits, and abnormal stress reactivity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Federspiel, Andrea and Wiest, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2162-3279

Publisher:

Wiley

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

07 Oct 2019 16:57

Last Modified:

22 Oct 2019 23:27

Publisher DOI:

10.1002/brb3.1397

PubMed ID:

31557426

Uncontrolled Keywords:

anticipation delivery fMRI reward stress striatum working memory

BORIS DOI:

10.7892/boris.133713

URI:

https://boris.unibe.ch/id/eprint/133713

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