Radiofrequency ablation lesion assessment using optical coherence tomography - a proof-of-concept study.

Deming, Liang; Taeschler, Dominik; Göpfert, Christine; Arnold, Patrik; Zurbuchen, Adrian; Sweda, Romy; Reichlin, Tobias; Tanner, Hildegard; Roten, Laurent; Häberlin, Andreas (2019). Radiofrequency ablation lesion assessment using optical coherence tomography - a proof-of-concept study. Journal of cardiovascular electrophysiology, 30(6), pp. 934-940. Wiley-Blackwell 10.1111/jce.13917

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BACKGROUND Radiofrequency catheter ablation (RFA) is an effective treatment for atrial fibrillation. However, ablation lesions are usually only assessed functionally. The immediate effect of RFA on the tissue is not directly visualized. Optical coherence tomography (OCT) is an imaging technique that uses light to capture high-resolution images with histology-like quality. Therefore, it might be used for high-precision imaging of ablation lesions. METHODS AND RESULTS Radiofrequency ablation lesions (n = 25) were produced on the freshly excised left and right ventricular porcine endocardium. A Thermocool ST SF NAV ablation catheter (Biosense Webster Inc) and an EP-Shuttle ablation generator (Stockert GmbH) were used to produce ablation lesions with powers from 10 to 40 W (energies ranging from 100 Ws to 900 Ws). After ablation, the tissue was imaged with a swept source OCT system (at a wavelength of 1300 nm). Subsequently, the ablation lesions underwent the histological analysis. The ablation lesions could be visualized by OCT in all 17 samples with ablation powers ≥20 W, meanwhile, no lesion could be observed in the other eight samples with lower power (10 W). Lesion depths and lesion radiuses, as assessed by OCT, correlated well with those observed on the subsequent histological analysis (Spearman's r = 0.94, P < 0.001 and r = 0.84, P < 0.001). In addition, successful three-dimensional reconstructions of ablation lesions were performed. CONCLUSION OCT can provide a visual high-resolution assessment of ablation lesions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship > Cardiac Technology and Implantable Devices
04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research

UniBE Contributor:

Deming, Liang; Göpfert, Christine; Zurbuchen, Adrian; Sweda, Romy; Reichlin, Tobias Roman; Tanner, Hildegard; Roten, Laurent and Häberlin, Andreas

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

1045-3873

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Andreas David Heinrich Häberlin

Date Deposited:

08 Oct 2019 10:34

Last Modified:

23 Oct 2019 12:23

Publisher DOI:

10.1111/jce.13917

PubMed ID:

30883977

Uncontrolled Keywords:

ablation lesion atrial fibrillation (AF) imaging optical coherence tomography (OCT) radiofrequency

BORIS DOI:

10.7892/boris.133746

URI:

https://boris.unibe.ch/id/eprint/133746

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