The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies (PADs).

Jandus, Peter; Frias Boligan, Kayluz; Smith, David F; de Graauw, Elisabeth; Grimbacher, Bodo; Jandus, Camilla; Abdelhafez, Mai M; Despont, Alain; Bovin, Nicolai; Simon, Dagmar; Rieben, Robert; Simon, Hans-Uwe; Cummings, Richard D; von Gunten, Stephan (2019). The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies (PADs). Blood, 134(22), pp. 1941-1950. American Society of Hematology 10.1182/blood.2019001705

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Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific IgG exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires among different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, characterized by the common loss of Gala- and GalNAc-reactivity and disease-specific recognition of microbial, self-antigens and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the dimension and clinical implications of the immune system failure in individual patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe

UniBE Contributor:

Simon, Dagmar; Rieben, Robert; Simon, Hans-Uwe and von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-4971

Publisher:

American Society of Hematology

Language:

English

Submitter:

Sabrina Cookman

Date Deposited:

08 Oct 2019 11:05

Last Modified:

30 Nov 2019 01:31

Publisher DOI:

10.1182/blood.2019001705

PubMed ID:

31537530

BORIS DOI:

10.7892/boris.133755

URI:

https://boris.unibe.ch/id/eprint/133755

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