Schönenberger, Katja A; Reber, Emilie; Bally, Lia; Geiser, Thomas; Lin, Dagmar; Stanga, Zeno (2019). Nutritional assessment in adults with cystic fibrosis. Nutrition, 67-68, p. 110518. Elsevier 10.1016/j.nut.2019.05.010
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OBJECTIVES
Clinical experience with patients with cystic fibrosis (CF) suggests a nutritional risk in this population. In addition to the lung pathology, a main pathophysiologic concern is the viscous mucus blocking pancreatic ducts, leading to reduced production of pancreatic enzymes. Therefore, maldigestion and consequently malabsorption (particularly fat and fat-soluble vitamins) occur, resulting in steatorrhea, vitamin deficiencies, and subsequently manifest malnutrition. The aim of this study was to investigate the nutritional status and determine the prevalence of malnutrition in an adult Swiss CF cohort.
METHODS
This was an observational cohort study in which the nutritional status and dietary habits of patients with CF and healthy controls were compared. Assessment was based on the nutritional risk screening (NRS-2002), dietary habits (7-d dietary record), body composition (bioelectrical impedance analysis), anthropometrics, resting energy expenditure (REE; indirect calorimetry), and physical or mental function (hand-grip strength, Short Form-36 v2).
RESULTS
Nineteen patients (15 men, mean age 32 y) and 15 controls (8 men, mean age 49 y) were included. Eight patients (42%) were at nutritional risk (NRS-2002 ≥3). Patients had higher energy intake/body weight (P = 0.021) with lower body fat percentage (P < .001), body mass index (P = 0.030), and physical/mental health scores (P < 0.001) than controls. Energy intake was higher than REE in patients (P = 0.003), but not in controls (P = 0.373).
CONCLUSIONS
Prevalence of malnutrition was high in this CF cohort, coinciding with low body fat percentage and low body mass index despite high energy and protein intake. Energy requirements of patients with CF should be estimated as approximately twice the Harris-Benedict REE and 1.7 times indirect calorimetry REE, while ensuring adequate intake of pancreatic enzymes.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology |
UniBE Contributor: |
Reber, Emilie, Bally, Lia Claudia, Geiser, Thomas (A), Lin, Dagmar, Stanga, Zeno |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0899-9007 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Heidi Lobsiger |
Date Deposited: |
15 Oct 2019 15:57 |
Last Modified: |
29 Mar 2023 23:36 |
Publisher DOI: |
10.1016/j.nut.2019.05.010 |
PubMed ID: |
31473521 |
Uncontrolled Keywords: |
Cystic fibrosis Malnutrition Nutritional assessment Nutritional screening Pancreatic enzyme replacement therapy |
BORIS DOI: |
10.7892/boris.133912 |
URI: |
https://boris.unibe.ch/id/eprint/133912 |
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