Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health.

Ostrander, Elaine A; Wang, Guo-Dong; Larson, Greger; vonHoldt, Bridgett M; Davis, Brian W; Jagannathan, Vidya; Hitte, Christophe; Wayne, Robert K; Zhang, Ya-Ping (2019). Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health. National Science Review, 6(4), pp. 810-824. Oxford University Press 10.1093/nsr/nwz049

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Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Jagannathan, Vidya

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

2095-5138

Publisher:

Oxford University Press

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

17 Oct 2019 14:17

Last Modified:

24 Oct 2019 05:06

Publisher DOI:

10.1093/nsr/nwz049

PubMed ID:

31598383

Uncontrolled Keywords:

breed evolution genome-wide association studies (GWAS) genomics selection variation

BORIS DOI:

10.7892/boris.133922

URI:

https://boris.unibe.ch/id/eprint/133922

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