Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients.

Müller, Michael; Caporro, Matteo; Gast, Heidemarie; Pollo, Claudio; Wiest, Roland; Schindler, Kaspar; Rummel, Christian (2020). Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients. Human brain mapping, 41(2), pp. 467-483. Wiley-Blackwell 10.1002/hbm.24816

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Resection of the seizure generating tissue can be highly beneficial in patients with drug-resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely unavailable to visual EEG analysis, which is the current clinical practice. We examined linear and nonlinear interrelations between intracranial EEG signals regarding their spatial distribution and network characteristics. The analyzed signals were recorded immediately before clinical seizure onset in epilepsy patients who received a standardized electrode implantation targeting the mesiotemporal structures. The linear interrelation networks were predominantly locally connected and highly reproducible between patients. In contrast, the nonlinear networks had a clearly centralized structure, which was specific for the individual pathology. The nonlinear interrelations were overrepresented in the focal hemisphere and in patients with no or only rare seizures after surgery specifically in the resected tissue. Connections to the outside were predominantly nonlinear. In all patients without worthwhile improvement after resective treatment, tissue producing strong nonlinear interrelations was left untouched by surgery. Our findings indicate that linear and nonlinear interrelations play fundamentally different roles in preictal intracranial EEG. Moreover, they suggest nonlinear signal interrelations to be a marker of epileptogenic tissue and not a characteristic of the mesiotemporal structures. Our results corroborate the network-based nature of epilepsy and suggest the application of network analysis to support the planning of resective epilepsy surgery.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Müller, Michael; Caporro, Matteo; Gast, Heidemarie; Pollo, Claudio; Wiest, Roland; Schindler, Kaspar Anton and Rummel, Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1065-9471

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

21 Oct 2019 14:08

Last Modified:

04 Jan 2020 01:31

Publisher DOI:

10.1002/hbm.24816

PubMed ID:

31625670

Uncontrolled Keywords:

epilepsy epilepsy surgery linear network structure nonlinear quantitative EEG

BORIS DOI:

10.7892/boris.134053

URI:

https://boris.unibe.ch/id/eprint/134053

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