Electrical Impedance as a Biomarker for Inner Ear Pathology Following Lateral Wall and Peri-modiolar Cochlear Implantation.

Shaul, Chanan; Bester, Christofer W; Weder, Stefan; Choi, June; Eastwood, Hayden; Padmavathi, K V; Collins, Aaron; O'Leary, Stephen J (2019). Electrical Impedance as a Biomarker for Inner Ear Pathology Following Lateral Wall and Peri-modiolar Cochlear Implantation. Otology & neurotology, 40(5), e518-e526. Wolters Kluwer 10.1097/MAO.0000000000002227

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OBJECTIVES/HYPOTHESIS

Spikes in cochlear implant impedance are associated with inner ear pathology after implantation. Here, we correlate these spikes with episodes of hearing loss and/or vertigo, with a comparison between lateral wall and peri-modiolar electrode arrays.

METHODS

Seven hundred seventy recipients of Cochlear's slim-straight, lateral wall electrode (CI422), or peri-modiolar (CI512) electrode were investigated for impedance spikes. Impedance fluctuations were defined as a median rise of ≥ 4 kΩ across all intracochlear electrodes from baseline measurements taken 2 weeks after switch-on. Medical records were analyzed from 189 of the 770 patients.

RESULTS

The slim straight, lateral wall electrode was found to spike in impedance at a significantly higher rate than the peri-modiolar array (17% vs 12%). The peri-modiolar electrode tended to spike in impedance earlier than the slim-straight electrode. Impedance spikes were found to significantly correlate with medical events (hearing loss, vertigo, or tinnitus). Overall, in the "spike" group, 42 of 75 patients (56%) demonstrated a clinical event during the impedance spike, whereas 26 of 114 patients (22%) of the "non-spike" group had a clinical event. This significant difference existed with both implant types.

CONCLUSION

These results demonstrate a small, but significant increase in impedance spikes in lateral wall electrodes, and support the relationship between spikes in cochlear implant impedances and postoperative inner-ear events, including the loss of residual hearing and vertigo. Monitoring cochlear implant impedance may be a method for early detection, and so the prevention, of these events in the future.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Weder, Stefan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1537-4505

Publisher:

Wolters Kluwer

Language:

English

Submitter:

Stefan Weder

Date Deposited:

14 Jan 2020 15:30

Last Modified:

14 Jan 2020 15:30

Publisher DOI:

10.1097/MAO.0000000000002227

PubMed ID:

31083087

URI:

https://boris.unibe.ch/id/eprint/134069

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