Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females.

Ofori, Emmanuel K; Conde Alonso, Sonia; Correas-Gomez, Lorena; Carnero, Elvis A; Zwygart, Karin; Hugues, Henry; Bardy, Daniel; Hans, Didier; Dwyer, Andrew A; Amati, Francesca (2019). Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females. Clinical endocrinology, 90(3), pp. 433-439. Wiley 10.1111/cen.13921

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OBJECTIVE Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women. DESIGN Observational, cross-sectional study of healthy, community dwelling postmenopausal women. PATIENTS AND MEASUREMENTS Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry. RESULTS Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05). CONCLUSION Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

UniBE Contributor:

Zwygart, Karin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1365-2265

Publisher:

Wiley

Language:

English

Submitter:

Roland Kreis

Date Deposited:

21 Oct 2019 14:42

Last Modified:

24 Oct 2019 08:07

Publisher DOI:

10.1111/cen.13921

PubMed ID:

30575083

Uncontrolled Keywords:

body composition intermuscular adipose tissue regional adiposity sexual dimorphism superficial adipose tissue visceral adipose tissue

BORIS DOI:

10.7892/boris.134073

URI:

https://boris.unibe.ch/id/eprint/134073

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