Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium.

Bahls, Martin; Lorenz, Matthias W; Dörr, Marcus; Gao, Lu; Kitagawa, Kazuo; Tuomainen, Tomi-Pekka; Agewall, Stefan; Berenson, Gerald; Catapano, Alberico L; Norata, Giuseppe D; Bots, Michiel L; van Gilst, Wiek; Asselbergs, Folkert W; Brouwers, Frank P; Uthoff, Heiko; Sander, Dirk; Poppert, Holger; Hecht Olsen, Michael; Empana, Jean Philippe; Schminke, Ulf; ... (2020). Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium. European journal of preventive cardiology, 27(3), pp. 234-243. SAGE Publications 10.1177/2047487319877078

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AIMS Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. METHODS AND RESULTS An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. CONCLUSION Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2047-4873

Publisher:

SAGE Publications

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

29 Oct 2019 11:51

Last Modified:

08 Feb 2020 01:31

Publisher DOI:

10.1177/2047487319877078

PubMed ID:

31619084

Uncontrolled Keywords:

CVD biomarker Risk factors risk factor progression

BORIS DOI:

10.7892/boris.134095

URI:

https://boris.unibe.ch/id/eprint/134095

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