Biologics and stem cell-based therapies for rotator cuff repair.

Bianco, Spencer T.; Moser, Helen L.; Galatz, Leesa M.; Huang, Alice H. (2019). Biologics and stem cell-based therapies for rotator cuff repair. Annals of the New York Academy of Sciences, 1442(1), pp. 35-47. New York Academy of Sciences 10.1111/nyas.13918

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The rotator cuff is composed of several distinct muscles and tendons that function in concert to coordinate shoulder motion. Injuries to these tendons frequently result in permanent dysfunction and persistent pain. Despite considerable advances in operation techniques, surgical repair alone still does not fully restore rotator cuff function. This review focuses on recent research in the use of biologics and stem cell-based therapies to augment repair, highlighting promising avenues for future work and remaining challenges. While a number of animal models are used for rotator cuff studies, the anatomy of the rotator cuff varies dramatically between species. Since the rodent rotator cuff shares the most anatomical features with the human, this review will focus primarily on rodent models to enable consistent interpretation of outcome measures.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Moser, Helen Laura

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1749-6632

Publisher:

New York Academy of Sciences

Language:

English

Submitter:

Kathrin Aeschlimann

Date Deposited:

05 Nov 2019 12:45

Last Modified:

05 Nov 2019 12:53

Publisher DOI:

10.1111/nyas.13918

PubMed ID:

30008172

Uncontrolled Keywords:

injury rotator cuff stem cells tendon

BORIS DOI:

10.7892/boris.134138

URI:

https://boris.unibe.ch/id/eprint/134138

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