Obesity and smoking predict the results of two-stage exchange in septic revision hip arthroplasty: A cohort study.

Ahmad, Sufian S.; Orlik, Lea; Ahmad, Suhaib J. S.; Albers, Christoph E.; Siebenrock, Klaus A.; Klenke, Frank M. (2019). Obesity and smoking predict the results of two-stage exchange in septic revision hip arthroplasty: A cohort study. Orthopaedics & traumatology, surgery & research, 105(3), pp. 467-471. Elsevier 10.1016/j.otsr.2019.01.006

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BACKGROUND Prosthetic joint infection (PJI) is deemed to be the most serious complication following total hip arthroplasty. Obesity and smoking are known risk factors for PJI. However, the influence of these variables on infection free survival, of septic revision hip arthroplasty, is yet to be explored. The aim of this study was to determine the effect of obesity and smoking on the outcome of two-stage prosthetic exchange surgery. PATIENTS AND METHODS A consecutive series of 97 hips in 94 patients (69 male, 25 female, mean age 66±12 years), undergoing two-stage revision surgery for hip PJI, were investigated retrospectively, after a mean follow-up of 60 (24-170) months. Survival was estimated using Kaplan-Meyer curves. A multivariate cox-regression model was applied to test for the influence of smoking or obesity (BMI≥30) after adjusting 16 potential patient-dependant variables. HYPOTHESIS The study hypothesis was that smoking and high BMI are predictors for the failure of septic revision hip arthroplasty. Failure of septic revision hip arthroplasty was defined as failure to eradicate the infection or eradication of the infection but failure to preserve the arthroplasty. RESULTS Kaplan-Meier showed a cumulative survival proportion of 80.4%(standard error S.E 4%), of the definitive implant, at 5 years. Obese patients (BMI≥30) and smokers had a significantly lower 5-year survival of 60.9% (S.E 1%) and 50.6% (S.E 1.4%), respectively (p=0.001). DISCUSSION Obesity and smoking are both factors determining infection free survival in two-stage revision hip arthroplasty. Clinicians should be aware of potential complications and anticipate a higher likelihood of conversion to a Girdlestone resection or even amputation in this group of patients. LEVEL OF EVIDENCE III, retrospective cohort study.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Ahmad, Sufian; Albers, Christoph; Siebenrock, Klaus-Arno and Klenke, Frank M.


600 Technology > 610 Medicine & health








Kathrin Aeschlimann

Date Deposited:

31 Oct 2019 09:56

Last Modified:

31 Oct 2019 10:06

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Obesity Prosthetic joint infection Revision hip arthroplasty Smoking Two-stage





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