Transmission of and susceptibility to seasonal influenza in Switzerland from 2003 to 2015.

Brugger, Jon; Althaus, Christian L. (2020). Transmission of and susceptibility to seasonal influenza in Switzerland from 2003 to 2015. Epidemics, 30, p. 100373. Elsevier 10.1016/j.epidem.2019.100373

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Understanding the seasonal patterns of influenza transmission is critical to help plan public health measures for the management and control of epidemics. Mathematical models of infectious disease transmission have been widely used to quantify the transmissibility of and susceptibility to past influenza seasons in many countries. The objective of this study was to obtain a detailed picture of the transmission dynamics of seasonal influenza in Switzerland from 2003 to 2015. To this end, we developed a compartmental influenza transmission model taking into account social mixing between different age groups and seasonal forcing. We applied a Bayesian approach using Markov chain Monte Carlo (MCMC) methods to fit the model to the reported incidence of influenza-like-illness (ILI) and virological data from Sentinella, the Swiss Sentinel Surveillance Network. The maximal basic reproduction number, R0, ranged from 1.46 to 1.81 (median). Median estimates of susceptibility to influenza ranged from 29% to 98% for different age groups, and typically decreased with age. We also found a decline in ascertainability of influenza cases with age. Our study illustrates how influenza surveillance data from Switzerland can be integrated into a Bayesian modeling framework in order to assess age-specific transmission of and susceptibility to influenza.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Althaus, Christian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1755-4365

Publisher:

Elsevier

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

29 Oct 2019 12:44

Last Modified:

16 Apr 2020 15:53

Publisher DOI:

10.1016/j.epidem.2019.100373

PubMed ID:

31635972

Uncontrolled Keywords:

Basic reproduction number Influenza Mathematical model Surveillance Switzerland

BORIS DOI:

10.7892/boris.134297

URI:

https://boris.unibe.ch/id/eprint/134297

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