Carlevaro-Fita, Joana; Johnson, Rory (2019). Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization. Molecular cell, 73(5), pp. 869-883. Cell Press 10.1016/j.molcel.2019.02.008
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The localization of long noncoding RNAs (lncRNAs) within the cell is the primary determinant of their molecular functions. LncRNAs are often thought of as chromatin-restricted regulators of gene transcription and chromatin structure. However, a rich population of cytoplasmic lncRNAs has come to light, with diverse roles including translational regulation, signaling, and respiration. RNA maps of increasing resolution and scope are revealing a subcellular world of highly specific localization patterns and hint at sequence-based address codes specifying lncRNA fates. We propose a new framework for analyzing sequencing-based data, which suggests that numbers of cytoplasmic lncRNA molecules rival those in the nucleus. New techniques promise to create high-resolution, transcriptome-wide maps associated with all organelles of the mammalian cell. Given its intimate link to molecular roles, subcellular localization provides a means of unlocking the mystery of lncRNA functions.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Carlevaro Fita, Joana, Johnson, Rory Baldwin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1097-2765 |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
04 Nov 2019 15:51 |
Last Modified: |
05 Dec 2022 15:31 |
Publisher DOI: |
10.1016/j.molcel.2019.02.008 |
PubMed ID: |
30849394 |
BORIS DOI: |
10.7892/boris.134310 |
URI: |
https://boris.unibe.ch/id/eprint/134310 |