Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy.

Rossi Sebastiano, Matteo; Konstantinidou, Georgia (2019). Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy. International journal of molecular sciences, 20(15) Molecular Diversity Preservation International MDPI 10.3390/ijms20153624

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The deregulation of cancer cell metabolic networks is now recognized as one of the hallmarks of cancer. Abnormal lipid synthesis and extracellular lipid uptake are advantageous modifications fueling the needs of uncontrolled cancer cell proliferation. Fatty acids are placed at the crossroads of anabolic and catabolic pathways, as they are implicated in the synthesis of phospholipids and triacylglycerols, or they can undergo β-oxidation. Key players to these decisions are the long-chain acyl-CoA synthetases, which are enzymes that catalyze the activation of long-chain fatty acids of 12-22 carbons. Importantly, the long-chain acyl-CoA synthetases are deregulated in many types of tumors, providing a rationale for anti-tumor therapeutic opportunities. The purpose of this review is to summarize the last up-to-date findings regarding their role in cancer, and to discuss the related emerging tumor targeting opportunities.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Rossi Sebastiano, Matteo and Konstantinidou, Georgia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Celine Joray

Date Deposited:

04 Nov 2019 14:15

Last Modified:

13 Mar 2021 02:04

Publisher DOI:

10.3390/ijms20153624

PubMed ID:

31344914

Uncontrolled Keywords:

ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 cancer cancer therapy fatty acid lipid metabolism therapy target

BORIS DOI:

10.7892/boris.134394

URI:

https://boris.unibe.ch/id/eprint/134394

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