68Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer-a modified protocol compared with the common protocol.

Haupt, Fabian; Dijkstra, Lotte; Alberts, Ian; Sachpekidis, Christos; Fech, Viktor; Boxler, Silvan; Gross, Tobias; Holland-Letz, Tim; Zacho, Helle D; Haberkorn, Uwe; Rahbar, Kambiz; Rominger, Axel; Afshar-Oromieh, Ali (2020). 68Ga-PSMA-11 PET/CT in patients with recurrent prostate cancer-a modified protocol compared with the common protocol. European journal of nuclear medicine and molecular imaging, 47(3), pp. 624-631. Springer-Verlag 10.1007/s00259-019-04548-5

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PURPOSE 68Ga-PSMA-11 PET/CT is commonly performed at 1 h post injection (p.i.). However, various publications have demonstrated that most prostate cancer (PC) lesions exhibit higher contrast at later imaging. The aim of this study was to compare the "common" protocol of 68Ga-PSMA-11 PET/CT with a modified protocol. METHODS In 2017, we used the following scanning protocol for 68Ga-PSMA-11 PET/CT in patients with recurrent PC: acquisition at 1 h p.i. without further preparations. From 2018, all scans were conducted at 1.5 h p.i. In addition, patients were orally hydrated with 1 L of water 0.5 h p.i. and were injected with 20 mg of furosemide 1 h p.i. Both protocols including 112 patients (2017) and 156 (modified protocol in 2018) were retrospectively compared. Rates of pathologic scans, maximum standardized uptake values (SUVmax), and tumor contrast (ratio lesion-SUVmax/background-SUVmean) as well as average standardized uptake values (SUVmean) of urinary bladder were analyzed. RESULTS Both tumor contrast and tracer uptake were significantly (p < 0.001) higher in the novel protocol. Although statistically not significant, the rates of pathologic scans were also higher in the modified protocol: 76.3% vs. 68.8% for all PSA values including 38.9% vs. 25.0% for PSA < 0.5 ng/ml and 60.0% vs. 56.7% for PSA > 0.5-≤ 2.0 ng/ml. Average SUVmean of the urinary bladder was significantly (p < 0.001) lower with the modified protocol. CONCLUSIONS The modified protocol, which includes a combination of delayed image acquisition at 1.5 h p.i., hydration, and furosemide resulted in higher tumor contrast and seems to have the potential to increase the rates of pathological scans, especially at low PSA levels.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Haupt, Fabian; Alberts, Ian Leigh; Sachpekidis, Christos; Fech, Viktor; Boxler, Silvan; Gross, Tobias; Rominger, Axel Oliver and Afshar Oromieh, Ali

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer-Verlag

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

06 Nov 2019 15:57

Last Modified:

08 Feb 2020 01:31

Publisher DOI:

10.1007/s00259-019-04548-5

PubMed ID:

31673789

Uncontrolled Keywords:

68Ga-PSMA-11 Furosemide Hydration PET/CT PSMA Prostate cancer Prostate-specific membrane antigen Protocol

BORIS DOI:

10.7892/boris.134562

URI:

https://boris.unibe.ch/id/eprint/134562

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