Ding, Jie; Guo, Jincheng; Wang, Liming; Chen, Yandong; Hu, Bin; Li, Yiye; Huang, Rujin; Cao, Junji; Zhao, Yuliang; Geiser, Marianne; Miao, Qing; Liu, Ying; Chen, Chunying (2019). Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface. Environmental science & technology, 53(15), pp. 9128-9138. ACS Publications 10.1021/acs.est.9b00399
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The Spring Festival is the most important holiday in China. During this time, the levels of particulate matter (PM) as well as gaseous copollutants significantly increase because of the widespread enjoyment of fireworks. The expression patterns of microRNAs may serve as valuable signatures of exposure to environmental constituents. We exposed macrophages to the whole stream of outdoor air at the air-liquid interface aiming at closely approximating the physiological conditions and the inhalation situation in the lung. 58 miRNAs were up-regulated, and 68 miRNAs were down-regulated in the night of the New Year's Eve (exposure group E2N1) compared to filtered-air exposed control cells. The target genes of the up-regulated miRNAs were enriched in immunity- and inflammation-linked pathways, such as the TLR-NF-κB pathway. Compared to the E2N1 group, 29 miRNAs were up-regulated, and 23 miRNAs were down-regulated in the cells exposed to air from the daytime of the Chinese New Year with higher concentrations of particles, SO2, and nitrogen oxide. The target genes of the up-regulated miRNAs were mostly enriched in apoptosis, adhesion, and junction-related pathways. These results preliminarily unravel part of the toxic mechanisms of air constituents and provide clues for discovering the main drivers of air pollution-induced disorders.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology |
UniBE Contributor: |
Geiser, Marianne |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0013-936X |
Publisher: |
ACS Publications |
Language: |
English |
Submitter: |
Marianne Geiser Kamber |
Date Deposited: |
11 Nov 2019 11:52 |
Last Modified: |
05 Dec 2022 15:32 |
Publisher DOI: |
10.1021/acs.est.9b00399 |
PubMed ID: |
31268311 |
BORIS DOI: |
10.7892/boris.134598 |
URI: |
https://boris.unibe.ch/id/eprint/134598 |
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