Dendritic cell/cytokine-induced killer cell-based immunotherapy in lung cancer: What we know and future landscape.

Mohsenzadegan, Monireh; Peng, Ren-Wang; Roudi, Raheleh (2020). Dendritic cell/cytokine-induced killer cell-based immunotherapy in lung cancer: What we know and future landscape. Journal of cellular physiology, 235(1), pp. 74-86. Wiley 10.1002/jcp.28977

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Multiple modalities for lung cancer therapy have emerged in the past decade, whereas their clinical applications and survival-beneficiary is little known. Vaccination with dendritic cells (DCs) or DCs/cytokine-induced killer (CIK) cells has shown limited success in the treatment of patients with advanced non-small-cell lung cancer. To evaluate and overcome these limitations in further studies, in the present review, we sum up recent progress about DCs or DCs/CIKs-based approaches for preclinical and clinical trials in patients with lung cancer and discuss some of the limited therapeutic success. Moreover, this review highlights the need to focus future studies on the development of new approaches for successful immunotherapy in patients with lung cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Thoraxchirurgie

UniBE Contributor:

Peng, Ren-Wang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9541

Publisher:

Wiley

Language:

English

Submitter:

Thomas Michael Marti

Date Deposited:

22 Nov 2019 15:13

Last Modified:

22 Nov 2019 15:13

Publisher DOI:

10.1002/jcp.28977

PubMed ID:

31222740

Uncontrolled Keywords:

cytokine-induced killer cells (CIKs) dendritic cells immunotherapy lung cancer

BORIS DOI:

10.7892/boris.134641

URI:

https://boris.unibe.ch/id/eprint/134641

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