Antigen array for serological diagnosis and novel allergen identification in severe equine asthma.

White, S J; Moore-Colyer, M; Marti, E; Hannant, D; Gerber, Vinzenz; Coüetil, L; Richard, E A; Alcocer, M (2019). Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific reports, 9(1), p. 15170. Springer Nature 10.1038/s41598-019-51820-7

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Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse's environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Gerber, Vinzenz

Subjects:

600 Technology > 630 Agriculture

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Ursula Therese Horst

Date Deposited:

04 Dec 2019 17:28

Last Modified:

08 Dec 2019 02:45

Publisher DOI:

10.1038/s41598-019-51820-7

PubMed ID:

31645629

BORIS DOI:

10.7892/boris.134646

URI:

https://boris.unibe.ch/id/eprint/134646

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