Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.

Castro Dias, Mariana; Mapunda, Josephine A.; Vladymyrov, Mykhailo; Engelhardt, Britta (2019). Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. International journal of molecular sciences, 20(21) Molecular Diversity Preservation International MDPI 10.3390/ijms20215372

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The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothelial arachnoid barrier and the glia limitans. Here, we summarize current knowledge of the cellular composition of the brain barriers with a specific focus on describing the molecular constituents of their junctional complexes. We propose that the brain barriers maintain CNS immune privilege by dividing the CNS into compartments that differ with regard to their role in immune surveillance of the CNS. We close by providing a brief overview on experimental tools allowing for reliable in vivo visualization of the brain barriers and their junctional complexes and thus the respective CNS compartments.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
09 Interdisciplinary Units > Microscopy Imaging Center (MIC)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Mota Castro Dias, Mariana; Mapunda, Josephine Angelo; Vladymyrov, Mykhailo and Engelhardt, Britta

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

13 Nov 2019 09:17

Last Modified:

13 Nov 2019 09:17

Publisher DOI:

10.3390/ijms20215372

PubMed ID:

31671721

Uncontrolled Keywords:

adherens junctions arachnoid barrier blood-brain barrier blood-cerebrospinal fluid barrier brain barriers glia limitans neurovascular unit tight junctions

BORIS DOI:

10.7892/boris.134671

URI:

https://boris.unibe.ch/id/eprint/134671

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