The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study

Gantenbein-Ritter, Benjamin; Chan, Samantha C W (2012). The evolutionary importance of cell ratio between notochordal and nucleus pulposus cells: an experimental 3-D co-culture study. European spine journal, 21 Suppl 6, S819-S825. Berlin: Springer-Verlag 10.1007/s00586-011-2026-9

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Notochordal cells and nucleus pulposus cells are co-existing in the intervertebral disc at various ratios among different mammalians. This fact rises the question about the interactions and the evolutionary relevance of this phenomenon. It has been described that these relatively large notochordal cells are mainly dominant in early lifetime of all vertebrates and then differences occur with ageing. Human, cattle, sheep, and goat lose the cells with age, whereas rodents and lagomorphs maintain these throughout their lifetime.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB
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UniBE Contributor:

Gantenbein, Benjamin and Chan, Samantha

ISSN:

0940-6719

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

25 Oct 2019 03:14

Publisher DOI:

10.1007/s00586-011-2026-9

PubMed ID:

21953383

BORIS DOI:

10.7892/boris.13468

URI:

https://boris.unibe.ch/id/eprint/13468 (FactScience: 219998)

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