Lymphatic outflow of cerebrospinal fluid is reduced in glioma.

Ma, Qiaoli; Schlegel, Felix; Bachmann, Samia B; Schneider, Hannah; Decker, Yann; Rudin, Markus; Weller, Michael; Proulx, Steven T.; Detmar, Michael (2019). Lymphatic outflow of cerebrospinal fluid is reduced in glioma. Scientific reports, 9(1), p. 14815. Springer Nature 10.1038/s41598-019-51373-9

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Glioblastoma is a malignant brain tumor with mean overall survival of less than 15 months. Blood vessel leakage and peritumoral edema lead to increased intracranial pressure and augment neurological deficits which profoundly decrease the quality of life of glioblastoma patients. It is unknown how the dynamics of cerebrospinal fluid (CSF) turnover are affected during this process. By monitoring the transport of CSF tracers to the systemic blood circulation after infusion into the cisterna magna, we demonstrate that the outflow of CSF is dramatically reduced in glioma-bearing mice. Using a combination of magnetic resonance imaging (MRI) and near-infrared (NIR) imaging, we found that the circulation of CSF tracers was hindered after cisterna magna injection with reduced signals along the exiting cranial nerves and downstream lymph nodes, which represent the major CSF outflow route in mice. Due to blockage of the normal routes of CSF bulk flow within and from the cranial cavity, CSF tracers were redirected into the spinal space. In some mice, impaired CSF clearance from the cranium was compensated by a lymphatic outflow from the sacral spine.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

13 Nov 2019 15:29

Last Modified:

24 Nov 2019 02:44

Publisher DOI:

10.1038/s41598-019-51373-9

PubMed ID:

31616011

BORIS DOI:

10.7892/boris.134684

URI:

https://boris.unibe.ch/id/eprint/134684

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