Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels.

Ma, Qiaoli; Decker, Yann; Müller, Andreas; Ineichen, Benjamin V; Proulx, Steven T. (2019). Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels. Journal of experimental medicine, 216(11), pp. 2492-2502. Rockefeller University Press 10.1084/jem.20190351

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The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end of the spine. Outflow of CSF tracers from the spinal subarachnoid space occurred predominantly from intravertebral regions of the sacral spine to lymphatic vessels, leading to sacral and iliac LNs. Clearance of CSF from the spine to lymphatic vessels may have significance for many conditions, including multiple sclerosis and spinal cord injury.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1540-9538

Publisher:

Rockefeller University Press

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

13 Nov 2019 09:36

Last Modified:

28 Feb 2020 02:30

Publisher DOI:

10.1084/jem.20190351

PubMed ID:

31455602

BORIS DOI:

10.7892/boris.134685

URI:

https://boris.unibe.ch/id/eprint/134685

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