Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation.

Vranova, Martina; Friess, Mona C; Haghayegh Jahromi, Neda; Collado-Diaz, Victor; Vallone, Angela; Hagedorn, Olivia; Jadhav, Maria; Willrodt, Ann-Helen; Polomska, Anna; Leroux, Jean-Christophe; Proulx, Steven Thomas; Halin, Cornelia (2019). Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation. Scientific reports, 9(1), p. 11714. Springer Nature 10.1038/s41598-019-48046-y

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The interleukin 7 receptor alpha chain (IL-7Rα) is predominately expressed by lymphocytes, and activation by its ligand IL-7 supports the development and maintenance of T cells and boosts T-cell mediated immunity. We recently reported that lymphatic endothelial cells (LECs) in dermal lymphatics also express IL-7 and its receptor chains (IL-7Rα and CD132) and that IL-7 supports lymphatic drainage. This suggested that activation of IL-7Rα signaling in lymphatics could exert inflammation-resolving activity, by promoting the clearance of excess tissue fluid. Here we investigated how the potentially opposing effects of IL-7Rα signaling in immune cells and in the lymphatic vasculature would affect the development and progression of psoriasis-like skin inflammation. We found that during acute and chronic skin inflammation mice with an endothelial-specific deletion of IL-7Rα (IL-7RαΔEC mice) developed more edema compared to control mice, as a consequence of impaired lymphatic drainage. However, systemic treatment of wild-type mice with IL-7 exacerbated edema and immune cell infiltration in spite of increasing lymphatic drainage, whereas treatment with IL-7Rα blocking antibody ameliorated inflammatory symptoms. These data identify IL-7Rα signaling as a new pathway in psoriasis-like skin inflammation and show that its pro-inflammatory effects on the immune compartment override its anti-inflammatory, drainage-enhancing effects on the endothelium.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Haghayegh Jahromi, Neda, Proulx, Steven Thomas


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




Springer Nature




Ursula Zingg-Zünd

Date Deposited:

13 Nov 2019 15:32

Last Modified:

05 Dec 2022 15:32

Publisher DOI:


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