An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth.

Yoon, Sun-Young; Dieterich, Lothar C; Karaman, Sinem; Proulx, Steven T.; Bachmann, Samia B; Sciaroni, Carol; Detmar, Michael (2019). An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth. PLoS ONE, 14(7), e0220341. Public Library of Science 10.1371/journal.pone.0220341

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The lymphatic vascular system plays important roles in the control of tissue fluid homeostasis and immune responses. While VEGF-A-induced angiogenesis promotes hair follicle (HF) growth, the potential role of lymphatic vessels (LVs) in HF cycling has remained unknown. In this study, we found that LVs are localized in close proximity to the HF bulge area throughout the postnatal and depilation-induced hair cycle in mice and that a network of LVs directly connects the individual HFs. Increased LV density in the skin of K14-VEGF-C transgenic mice was associated with prolongation of anagen HF growth. Conversely, HF entry into the catagen phase was accelerated in K14-sVEGFR3 transgenic mice that lack cutaneous LVs. Importantly, repeated intradermal injections of VEGF-C promoted hair growth in mice. Conditioned media from lymphatic endothelial cells promoted human dermal papilla cell (DPC) growth and expression of IGF-1 and alkaline phosphatase, both activators of DPCs. Our results reveal an unexpected role of LVs in coordinating and promoting HF growth and identify potential new therapeutic strategies for hair loss-associated conditions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Proulx, Steven Thomas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

12 Nov 2019 10:05

Last Modified:

24 Nov 2019 02:44

Publisher DOI:

10.1371/journal.pone.0220341

PubMed ID:

31344105

BORIS DOI:

10.7892/boris.134688

URI:

https://boris.unibe.ch/id/eprint/134688

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