Biomaterials for Intervertebral Disc Regeneration

Gantenbein-Ritter, Benjamin; Sakai, Daisuke (2011). Biomaterials for Intervertebral Disc Regeneration. In: Ducheyne, Paul; Healy, Kevin (eds.) Comprehensive Biomaterials. Biomaterials and Clinical Use: Vol. 6 (pp. 161-169). Amsterdam: Elsevier 10.1016/B978-0-08-055294-1.00210-5

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The intervertebral disc (IVD) is a complex avascular organ of viscoelastic properties. The current research focus is to regenerate and to partially restore a degenerated IVD by ‘smart’ biomaterials in combination of cell therapy and/or growth factors. For the two tissues of the IVD, that is, the nucleus pulposus (NP) and the annulus fibrosus (AF), biomaterials of different mechanical properties are needed. The ideal biomaterial to restore the water-rich NP and the tensile-force resistant AF has not been identified yet. The lack of blood vessels and the relative scarcity of specially adapted cells of the IVD organ demand novel concepts of tissue-engineered biological approaches to regenerate or replace the IVD. Injectable biodegradable hydrogels with swelling properties are in focus for NP replacement, whereas electrospun biphasic composites and silk, among other biodegradable polymers, are discussed for AF reinforcement.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Gantenbein, Benjamin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISBN:

978-0-08-055294-1

Series:

Biomaterials and Clinical Use

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

02 Jan 2015 06:54

Publisher DOI:

10.1016/B978-0-08-055294-1.00210-5

Uncontrolled Keywords:

Alginate, Annulus fibrosus, Atellocollagen, Ceramics, Chitosan, Collagen, Electrospinning, Fusion, Hyaluronan, Hydrogel, Intervertebral disc, Nucleus pulposus, Poly ethylene glycol, Silk

BORIS DOI:

10.7892/boris.13469

URI:

https://boris.unibe.ch/id/eprint/13469 (FactScience: 220008)

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