Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours.

Wiesli, Peter; Pavlicek, Vojtech; Brändle, Michael; Pfammatter, Thomas; Perren, Aurel; Schmid, Christoph (2019). Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours. Endocrinology, diabetes & metabolism, 2(4), e00083. Wiley 10.1002/edm2.83

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Introduction

Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas. However, the mechanism of hypoglycaemia in patients with somatostatinomas has not been well characterized.

Methods

We describe two patients with recurrent neuroglycopenic episodes caused by somatostatin-secreting neuroendocrine tumours in the liver, detected by abdominal CTs and whole-body octreotide scintigraphy scans and confirmed by biopsy.

Results

Pancreatic islet hyperplasia and co-secretion of insulin (in addition to somatostatin) from tumour cells, respectively, have been characterized as completely distinct mechanisms of hypoglycaemia at both the functional and morphological levels in these two patients.

Conclusions

Hypoglycaemia may be caused by different mechanisms in patients with somatostatinomas.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2398-9238

Publisher:

Wiley

Language:

English

Submitter:

Aurel Perren

Date Deposited:

13 Nov 2019 15:58

Last Modified:

28 Nov 2020 02:30

Publisher DOI:

10.1002/edm2.83

PubMed ID:

31592116

Uncontrolled Keywords:

hyperinsulinaemia hypoglycaemia neuroendocrine tumour somatostatinoma

BORIS DOI:

10.7892/boris.134733

URI:

https://boris.unibe.ch/id/eprint/134733

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