Erratic movement disorders disclosing Graves' disease and paralleling thyroid function but not autoantibody levels.

Delhasse, Sébastien; Debove, Ines; Arnold-Kunz, Gabriella; Ghika, Joseph-André; Chabwine, Joelle Nsimire (2019). Erratic movement disorders disclosing Graves' disease and paralleling thyroid function but not autoantibody levels. Journal of international medical research, 47(3), pp. 1378-1386. Sage 10.1177/0300060518816873

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Graves' disease (GD) is an autoimmune pathology characterized by hyperthyroidism and the presence of specific anti-thyroid antibodies. Neurological symptoms such as seizures, cognitive impairment, and tremor can be observed during the course of GD, but more complex movement disorders such as chorea and myoclonus are less frequent. The mechanisms underlying movement disorders in GD are not fully understood. While some authors relate movement disorders to thyroid dysfunction, others claim an autoimmune origin. We herein report a case involving a 60-year-old woman who presented with erratic, intricate movement disorders for which a medical workup revealed GD. During the 2-year follow-up period, her neurological symptoms evolved in parallel with her thyroid function, but not with her autoimmune anti-thyroid antibody level. Her neurological symptoms completely disappeared when she became euthyroid. We herein discuss the complicated clinicobiological relationship between thyroid function and movement disorders. This relationship involves several factors, including the impact of radioactive treatment. The present case emphasizes the importance of including thyroid function screening in the workup of unexplained movement disorders.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Debove, Ines


600 Technology > 610 Medicine & health








Chantal Kottler

Date Deposited:

14 Nov 2019 09:08

Last Modified:

14 Nov 2019 09:14

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Graves’ disease Movement disorders autoimmune chorea hyperthyroidism myoclonus tremor




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