Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy.

Ambrosius, Björn; Gold, Ralf; Chan, Andrew; Faissner, Simon (2019). Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy. Neurology: Neuroimmunology and Neuroinflammation, 6(3), e551. Wolters Kluwer Health 10.1212/NXI.0000000000000551

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Today, HIV-infected (HIV+) patients can be treated efficiently with combined antiretroviral therapy (cART), leading to long-term suppression of viral load, in turn increasing life expectancy. While cART reduced the occurrence of HIV-associated dementia, the prevalence of subtle forms of HIV-associated neurocognitive disorders (HAND) is unchanged. This is related to persistent immune activation within the CNS, which is not addressed by cART. Pathologic processes leading to HAND consist of the release of proinflammatory cytokines, chemokines, reactive oxygen metabolites and glutamate, and the release of HIV proteins. Some of those processes can be targeted using medications with immunomodulatory and neuroprotective properties such as dimethyl fumarate, teriflunomide, or minocycline. In this review, we will summarize the knowledge about key pathogenic processes involved in HAND and potential therapeutic avenues to target HAND.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Chan, Andrew Hao-Kuang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2332-7812

Publisher:

Wolters Kluwer Health

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

14 Nov 2019 09:42

Last Modified:

14 Nov 2019 09:49

Publisher DOI:

10.1212/NXI.0000000000000551

PubMed ID:

31119186

BORIS DOI:

10.7892/boris.134796

URI:

https://boris.unibe.ch/id/eprint/134796

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