Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond.

Bouthour, Walid; Mégevand, Pierre; Donoghue, John; Lüscher, Christian; Birbaumer, Niels; Krack, Paul (2019). Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond. Nature reviews. Neurology, 15(6), pp. 343-352. Springer Nature 10.1038/s41582-019-0166-4

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Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires laborious open-loop programming, which can mitigate the benefits of this treatment. Experimental closed-loop DBS systems are emerging that can sense the electrophysiological surrogates of PD motor signs and respond with delivery of an automatically adapted stimulation. Such biomarker-based neural interfaces constitute a major advance towards improving the outcomes of patients treated with DBS and enhancing our understanding of the pathophysiological mechanisms underlying PD. In this Perspectives article, we argue that closed-loop DBS, in addition to offering advantages in patients with PD, might extend the current indications for DBS to include selected psychiatric disorders in which the symptoms are similarly driven by pathological brain circuit activity. The success of closed-loop DBS in such settings will depend on the identification of symptom-specific biomarkers, which ideally should reflect causal mechanisms of the underlying pathology.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krack, Paul

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1759-4766

Publisher:

Springer Nature

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

14 Nov 2019 09:50

Last Modified:

19 Dec 2019 12:21

Publisher DOI:

10.1038/s41582-019-0166-4

Related URLs:

PubMed ID:

30936569

BORIS DOI:

10.7892/boris.134799

URI:

https://boris.unibe.ch/id/eprint/134799

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