Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial.

Knudsen, K; Krack, Paul; Tonder, L; Houeto, J-L; Rau, J; Schade-Brittinger, C; Hartmann, A; Hälbig, Thomas D; Paschen, Stephen; Barbe, Michael T; Kühn, Andrea; Fraix, Valerie; Brefel-Courbon, Christine; Vesper, Jan; Maltête, David; Sixel-Döring, Friederike; Weiss, Daniel; Witjas, Tatiana; Thobois, Stephane; Agid, Yves; ... (2019). Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial. Parkinsonism & related disorders, 65, pp. 217-223. Elsevier 10.1016/j.parkreldis.2019.05.023

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BACKGROUND Programming algorithms have never been tested for outcome. The EARLYSTIM study showed superior outcomes of deep brain stimulation of the subthalamic nucleus (STN-DBS) over best medical treatment in early Parkinson's disease (PD). Patients were programmed according to common guidelines but customized for each patient. METHODS Stimulation parameters were systematically documented at 1, 5, 12, and 24 month in the cohort of 114 patients who had bilateral STN-DBS at 24 month. We investigated the influence of atypical programming, changes of stimulated electrode contacts and stimulation energy delivered. Outcomes were the Unified Parkinson's Disease Rating Scale (UPDRS) motor and ADL-subscores, health-related quality of life (PDQ-39) summary index and mobility- and ADL-subscores. RESULTS At 1/5/12/24 months follow up, mean amplitude (1.8/2.5/2.6/2.8 V), impedance (1107/1286/1229/1189 Ω) and TEED (33.7/69.0/84.4/93.0 V2*μs*Hz/Ω) mainly increased in the first 5 months, while mean pulse width (60.0/62.5/65.1/65.8 μs), frequency (130/137.7/139.1/142.7 Hz) remained relatively stable. Typical programming (single monopolar electrode contact) was used in 80.7% of electrodes. Double monopolar (11/114) and bipolar (2/114) stimulation was only rarely required. There was no significant difference in clinical outcomes between the patient groups requiring contact changes (n = 32/28.1%) nor between typical (n = 83/72.8%) versus non-typical programming. Energy used for STN-DBS was higher for the dominant side of PD. CONCLUSION In the first 5 months an increase in amplitude is required to compensate for various factors. Monopolar stimulation is sufficient in 80% of patients at 24 months. Homogeneous stimulation strategies can account for the favorable outcomes reported in the Earlystim study.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krack, Paul

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1353-8020

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

14 Nov 2019 12:42

Last Modified:

14 Nov 2019 12:51

Publisher DOI:

10.1016/j.parkreldis.2019.05.023

PubMed ID:

31257096

BORIS DOI:

10.7892/boris.134824

URI:

https://boris.unibe.ch/id/eprint/134824

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